Invasion and fixation of sex-reversal genes.

I-17: The Mechanism of Gonadal Sex Determination

Background In mammals, a single exon gene SRY on the Y-chromosome is activated in the XY gonadal primordium and initiates a cascade of molecular and morphological events leading to testicular differentiation. SRY-encoded protein (SRY) is a transcription factor harboring a HMG-box DNAbinding motif that upregulates SOX9, which encodes another transcription factor sharing the DNA binding motif wit...

The Difference of Expression of 18 Genes in Axillary Invasion and Vascular Invasion Compared to Control Samples in Breast Cancer

Background & Objective: Recent studies from gene profiling have revealed some genes that are overexpressed in the epithelial-mesenchymal transition (EMT) process and are responsible for its initiation and activation resulting in tumor progression and metastasis. The present study aimed to assess the role of genes involved in the EMT process and the association of these genes wi...

Short communication:The effect of gokshura (Tribulus terrestris) and nettle root (Urtica dioica) extracts on growth rate and sex reversal in convict cichlid (Cichlasoma nigrofasciatum)

I-43: Identification of SOX3 as an XX MaleSex Reversal Gene in Mice and Jumans

Background: Mammals utilise an XX/XY system of sex determination in which the Y-linked gene SRY (Sexdetermining region Y) exerts a dominant masculinising influence on sexual development. Sex chromosome homology and comparative sequence studies suggest that SRY evolved from the related SOX3 gene on the X chromosome, although there is no direct functional evidence to support this hypothesis. The ...

The effect of Gokshura (Tribulus terrestris) and Nettle root (Urtica dioica) on growth rate and sex reversal of convict cichlid (Cichlasoma nigrofasciatum)

The aims of the present study were to investigate the effect of Gokshura and nettle root extracts on growth rate and sex reversal in Convict cichlid fish. Seven-day hatchlings were immersed in water containing 0 (Control, T1), 200 mg/l nettle root extract (T2), 300 mg/l nettle root extract (T3), 10 mg/l Gokshura extract (T4) and 10 mg/l Gokshura plus 200 mg/l nettle root extracts (T5) for two m...